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HLA Resources

High-Resolution HLA Alleles and Haplotypes in the US Population

The high-resolution frequencies have been updated as of December 2007, and represent an erratum to the original published frequencies. Please download the new frequency tables and updated manuscript tables and figures.

For complete details on this study, read the article:

Maiers, M., Gragert, L., Klitz, W. High resolution HLA alleles and haplotypes in the US population. Human Immunology (2007) 68, 779-788. 

Table 1 - Definition of alleles identical over antigen binding domain 

Table 2 - Total chromosome counts per allele and haplotype category 

Table 3 - Number of distinct alleles observed 

Table 4 - Hardy-Weinberg test results 

Table 5 - Haplotype sampling statistics 

Table 6 - Top 10 A-B-DRB1 frequencies compared by race/ethnic group 

Figure 1 - Frequency distribution of Top 25 A-B-DRB1 haploytypes 

Figure 2 - Haplotype frequency comparisons with full registry samples 

High Resolution HLA Alleles and Haplotypes in the US Population

HLA-A PDF  XLS   
HLA-B  PDF  XLS   
HLA-DRB1  PDF  XLS   
HLA-C PDF  XLS   
HLA-DQB1 PDF  XLS   
       
HLA-A-B PDF 

XLS 

  
HLA-A-B-DRB1  PDF  XLS   
HLA-A-B-DRB1-DQB1 PDF  XLS   
HLA-A-C-B PDF  XLS   
HLA-A-C-B-DRB1 PDF  XLS   
HLA-A-C-B-DRB1-DQB1  PDF  XLS   
HLA-B-DRB1 PDF  XLS   
HLA-C-B  PDF  XLS   
HLA-C-B-DRB1-DQB1 PDF  XLS   
HLA-DRB1-DQB1  PDF  XLS   
Human Immunology Manuscript Frequencies - 2006
Note: These frequencies are deprecated, but match the sample counts from the published September 2007 Human Immunology journal article. Individuals carrying HLA alleles (A*0201g and A*2402g) were systematically excluded from a subset of our population (roughly half of the minority groups: AFA, API, HIS) due to a technical issue with allele ambiguities and our failure to characterize these two allele groups as high-resolution.